DEPRESSION · PSYCHOLOGIST AND DOCTOR · NO REFERRAL

Depression – when low mood persists

Depression is more than ordinary sadness. It is a mental health condition in which low mood, reduced energy or loss of pleasure and interest persist and significantly affect everyday life.

Depression can make it difficult to manage work or studies, engage in relationships and handle daily tasks. It can also affect thoughts, feelings, sleep, appetite and the ability to experience joy.

For some, the low mood can feel like a protective layer over anger, grief or needs that have been hard to make room for. Depression is more common in people with ADHD, and here it is often reactive: a reaction to the increased demands that come with life transitions, such as education, work, relationships or parenthood.

Clinically reviewed by Martin Bergholtz, Medical Doctor in PsychiatryUpdated September 2026
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Typical Symptoms

01

Persistent Low Mood

Persistent sadness, emptiness, or feelings of despair.

02

Loss of Interest & Pleasure

Loss of joy in activities and interests you previously appreciated.

03

Sleep & Appetite Changes

Disrupted sleep patterns, altered appetite, or weight changes.

04

Low Energy & Fatigue

Sensation of exhaustion and everyday tasks requiring significantly more effort.

05

Difficulty Concentrating

Challenges with maintaining focus, remembering, and making everyday decisions.

06

Self-Criticism & Hopelessness

Negative thought patterns about yourself and the future take up substantial space.

Depression Affects the Whole Person

THOUGHTS

Self-criticism, hopelessness, and negative interpretations.

BODY

Fatigue, along with changes in sleep, appetite, and physical restlessness.

EMOTIONS

Persistent sadness, emptiness, guilt, or irritability.

BEHAVIOR

Withdrawal, reduced activity, and fewer positive experiences.

Depression is not a sign of weakness – and it can be treated.
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It Can Vary From Person to Person

Symptoms Vary

Not everyone experiences it the same way or with the same intensity.

Life Stressors Play In

Stress, loss, physical health, and life changes can increase vulnerability.

Mind & Body Interconnected

Physical and emotional reactions interact continuously in reciprocal cycles.

Help Makes a Difference

Treatment and structured support can alleviate symptoms and strengthen resilience.

What Happens in the Brain?

Depression is associated with changes in neural networks and brain functioning that influence motivation, reward processing, concentration, and emotional regulation. Findings vary between individuals; there is no single monolithic “depression brain”.

During Depression

Attenuated or imbalanced signaling between emotional and attentional networks.

During Gradual Recovery

Restored plasticity and balanced connectivity across brain networks.

With effective treatment, neural activity and connectivity in affected brain networks can gradually normalize.

Biological, psychological, and social factors interact.

How is Depression Treated?

Treatment is individually tailored and guided by the severity and nature of the depression.

Psychotherapy

Talking therapy helps identify unhelpful patterns and create space for feelings that have been challenging to acknowledge or express.

Medication

Antidepressant medication can relieve core symptoms and restore capacity for daily life. Carefully evaluated and monitored.

Everyday Support

Supportive relationships, daily routine, sleep hygiene, gentle exercise, and meaningful activities bolster recovery.

For moderate to severe depression, combining psychotherapy and medical treatment is often most effective.

Small Steps Can Create Movement

You do not need to see the entire journey ahead. Treatment can begin with what is possible right now – understanding your patterns, making space for feelings, and gradually rediscovering calm and meaning.

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